Kimberly
Hattie
Emily Stanton
Voice of Octavia Spencer (voice)
Grandma
The Manticore (voice)
Dab-Dab (voice)
Harriet Wilson
Sue Ann
Karen
Kelly Banks
Zelda Fuller
Roberta Taylor
Mrs. Barrett
Papa / Elouisa
Dorothy Vaughan
Opal
Linda Workman
Johanna Reyes
Mrs. Otterton (voice)
Miss Harris
Dr. Corman
Johanna Reyes
Rowena Jeffers
Aunt Honey
Angel Angelique
Loray
Nurse Keller
Martha (voice)
Tanya
Wanda
Narrator (voice)
Dr. Nance
LeSonia Robinson
Jenny
Madge Wiggins
Minny Jackson
Alison
Rhonda (Segment 5: Auto Motives)
Madame Nora
Rhonda Dooley
Rochelle
Nurse Daniels
Troubled Woman
Bank Co-Worker
Mrs. Hambrick
Detention Teacher
Kate the Home Health Care Nurse
Nurse
Streetwalker
Landlady
Big Customer
Octavia / Octavia - Bookstore
Ayisha Lebaron
Woman
Mrs. Battle
Stylist
Opal
Laqueta Mills
Neighbor in Alley
Security Guard
Unemployment Clerk
Waitress
Check-In Girl
Nurse B
Nurse #2
Black Belly
Elegant Guest (as Octavia L. Spencer)
Agnes Large
Twila
Baby Nurse
Waitress
Woman in Elevator
Shawna
Cynthia
Evelyn
Wanda
Nativity Watson
Roark's Nurse